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I will send thee far hence unto the Gentiles - This was the particular appointment of St. Paul: he was the apostle of the Gentiles; for, though he preached frequently to the Jews, yet to preach the Gospel to the Gentiles, and to write for the conversion and establishment of the Gentile world, were his peculiar destination. Hence we find him and his companions travelling every where; through Judea, Phoenicia, Arabia, Syria, Cilicia, Pisidia, Lycaonia, Pamphylia, Galatia, Phrygia, Macedonia, Greece, Asia, the Isles of the Mediterranean Sea, the Isles of the Aegean Sea, Italy, and some add Spain and even Britain. This was the diocess of this primitive bishop: none of the apostles traveled, none preached, none labored as this man; and, we may add, none was so greatly owned of God. The epistles of Peter, John, James, and Jude, are great and excellent; but, when compared with those of Paul, however glorious they may be, they have no glory comparatively, by reason of that glory which excelleth. Next to Jesus Christ, St. Paul is the glory of the Christian Church. Jesus is the foundation; Paul, the master-builder.

And he said unto me, Depart - Because the Christians at Jerusalem would not receive him.

Far hence - Paul traveled far in the pagan nations. A large part of his ministry was spent in remote countries, and in the most distant regions then known. See Romans 15:19.

After Paul's conversion, he visited Jerusalem and there preached Jesus and the wonders of His grace. He related his miraculous conversion, which so enraged the priests and rulers that they sought to take his life. But that he might be saved, Jesus again appeared to him in a vision while he was praying, and said unto him, “Get thee quickly out of Jerusalem: for they will not receive thy testimony concerning Me.” Paul answered, “Lord, they know that I imprisoned and beat in every synagogue them that believed on Thee: and when the blood of Thy martyr Stephen was shed, I also was standing by, and consenting unto his death, and kept the raiment of them that slew him.” Paul thought that the Jews in Jerusalem could not resist his testimony; that they would consider that the great change in him could be wrought only by the power of God. But the reply was more decided than before: “Depart: for I will send thee far hence unto the Gentiles.” EW 206.1

During Paul's absence from Jerusalem, he wrote many letters to different places, relating his experience and bearing a powerful testimony. But some strove to destroy the influence of those letters. They were forced to admit that his letters were weighty and powerful, but they declared that his bodily presence was weak and his speech contemptible. EW 206.2

Jesus here refers to a class who have no desire to escape from the slavery of sin. By indulgence in the corrupt and vile their natures have become so degraded that they cling to the evil and will not be separated from it. The servants of Christ should not allow themselves to be hindered by those who would make the gospel only a matter of contention and ridicule. MB 129.1

But the Saviour never passed by one soul, however sunken in sin, who was willing to receive the precious truths of heaven. To publicans and harlots His words were the beginning of a new life. Mary Magdalene, out of whom He cast seven devils, was the last at the Saviour's tomb and the first whom He greeted in the morning of His resurrection. It was Saul of Tarsus, one of the most determined enemies of the gospel, who became Paul the devoted minister of Christ. Beneath an appearance of hatred and contempt, even beneath crime and degradation, may be hidden a soul that the grace of Christ will rescue to shine as a jewel in the Redeemer's crown. MB 129.2

Upon hearing this, the disciples received him as one of their number. Soon they had abundant evidence as to the genuineness of his Christian experience. The future apostle to the Gentiles was now in the city where many of his former associates lived, and to these Jewish leaders he longed to make plain the prophecies concerning the Messiah, which had been fulfilled by the advent of the Saviour. Paul felt sure that these teachers in Israel, with whom he had once been so well acquainted, were as sincere and honest as he had been. But he had miscalculated the spirit of his Jewish brethren, and in the hope of their speedy conversion he was doomed to bitter disappointment. Although “he spake boldly in the name of the Lord Jesus, and disputed against the Grecians,” those who stood at the head of the Jewish church refused to believe, but “went about to slay him.” Sorrow filled his heart. He would willingly have yielded up his life if by that means he might bring some to a knowledge of the truth. With shame he thought of the active part he had taken in the martyrdom of Stephen, and now in his anxiety to wipe out the stain resting upon one so falsely accused, he sought to vindicate the truth for which Stephen had given his life. AA 129.1

Burdened in behalf of those who refused to believe, Paul was praying in the temple, as he himself afterward testified, when he fell into a trance; whereupon a heavenly messenger appeared before him and said, “Make haste, and get thee quickly out of Jerusalem: for they will not receive thy testimony concerning Me.” Acts 22:18. AA 130.1

Paul was inclined to remain at Jerusalem, where he could face the opposition. To him it seemed an act of cowardice to flee, if by remaining he might be able to convince some of the obstinate Jews of the truth of the gospel message, even if to remain should cost him his life. And so he answered, “Lord, they know that I imprisoned and beat in every synagogue them that believed on Thee: and when the blood of Thy martyr Stephen was shed, I was also standing by, and consenting unto his death, and kept the raiment of them that slew him.” But it was not in harmony with the purpose of God that His servant should needlessly expose his life; and the heavenly messenger replied, “Depart: for I will send thee far hence unto the Gentiles.” Acts 22:19-21. AA 130.2

His servants in like manner must go forth to sow. When called to become a sower of the seed of truth, Abraham was bidden, “Get thee out of thy country, and from thy kindred, and from thy father's house, unto a land that I will show thee.” [Genesis 12:1.] “And he went out, not knowing whither he went,” [Hebrews 11:8.] as God's lightbearer, to keep His name alive in the earth. He forsook his country, his home, his relatives, and all the pleasant associations connected with his earthly life, to become a pilgrim and a stranger. GW 112.1

So to the apostle Paul, praying in the temple at Jerusalem, came the message, “Depart: for I will send thee far hence unto the Gentiles.” [Acts 22:21.] So those who are called to unite with Christ must leave all in order to follow Him. Old associations must be broken up, plans of life relinquished, earthly hopes surrendered. In toil and tears, in solitude and through sacrifice, must the seed be sown. GW 112.2

Those who consecrate body, soul, and spirit to God, will constantly receive a new endowment of physical, mental, and spiritual power. The inexhaustible supplies of heaven are at their command. Christ gives them the breath of His own Spirit, the life of His own life. The Holy Spirit puts forth His highest energies to work in heart and mind. The grace of God enlarges and multiplies their faculties, and every perfection of the divine nature comes to their assistance in the work of saving souls. Through co-operation with Christ, they are made complete in Him, and in their human weakness they are enabled to do the deeds of Omnipotence. GW 112.3