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Romans 16:21

Adam Clarke
Bible Commentary

Timotheus my workfellow - This is on all hands allowed to be the same Timothy to whom St. Paul directs the two epistles which are still extant. See some account of him in the notes on Acts 16:1; (note), etc.

Lucius - This was probably Luke the evangelist, and writer of the book called The Acts of the Apostles. For a short account of him see the Preface to that book.

Jason - It is likely that this is the same person mentioned Acts 17:7, who at Thessalonica received the apostles into his house, and befriended them at the risk both of his property and life.

Sosipater - He was a Berean, the son of one Pyrrhus, a Jew, by birth, and accompanied St. Paul from Greece into Asia, and probably into Judea. See Acts 20:4.

Albert Barnes
Notes on the Whole Bible

Timotheus - Timothy; to whom the Epistles which bear his name were written. He was long the companion of Paul in his labors; Acts 16:1; 1 Corinthians 16:10; 2 Corinthians 1:1, 2 Corinthians 1:19; Philemon 2:29; 1 Thessalonians 3:2; 1 Timothy 1:2; Hebrews 13:23.

And Lucius - He is mentioned in Acts 13:1, as a prophet and teacher, a native of Cyrene. Nothing more is known of him.

My kinsmen - Romans 16:7.

Matthew Henry
Concise Bible Commentary
The apostle adds affectionate remembrances from persons with him, known to the Roman Christians. It is a great comfort to see the holiness and usefulness of our kindred. Not many mighty, not many noble are called, but some are. It is lawful for believers to bear civil offices; and it were to be wished that all offices in Christian states, and in the church, were bestowed upon prudent and steady Christians.