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The wine of the wrath - The punishment due to her transgressions, because they have partaken with her in her sins. See the note on Revelation 14:8.

For all nations have drunk of the wine of the wrath of her fornication - See the notes on Revelation 14:8. This is given as a reason why this utter ruin had come upon her. She had beguiled and corrupted the nations of the earth, leading them into estrangement from God, and into pollution and sin. See the notes on Revelation 9:20-21.

And the kings of the earth have committed fornication with her - Spiritual adultery; that is, she has been the means of seducing them from God and leading them into sinful practices.

And the merchants of the earth are waxed rich through the abundance of her delicacies - The word rendered “abundance” here, means commonly “power.” It might here denote influence, though it may also mean number, quantity, wealth. Compare Revelation 3:8, where the same word is used. The word rendered “delicacies” - στρῆνους strēnous- occurs nowhere else in the New Testament. It properly means rudeness, insolence, pride; and hence “revel, riot, luxury.” It may be rendered here properly as “luxury,” or “proud voluptuousness”; and the reference is to such luxuries as are found commonly in a great, a frivolous, and a splendid city. These, of course, give rise to much traffic, and furnish employment to many merchants and sailors, who thus procure a livelihood, or become wealthy as the result of such traffic. Babylon - or papal Rome - is here represented under the image of such a luxurious city; and of course, when she falls, they who have thus been dependent on her, and who have been enriched by her, have occasion for mourning and lamentation. It is not necessary to expect to find a literal fulfillment of this, for it is emblematic and symbolical. The image of a great, rich, splendid, proud and luxurious city having been employed to denote that anti-Christian power, all that is said in this chapter follows, of course, on its fall. The general idea is, that she was doomed to utter desolation, and that all who were connected with her, far and near, would be involved in her ruin.

On September 1, 1902, Mrs. White wrote: LS 412.1

“Well equipped tent meetings should be held in the large cities, such as San Francisco; for not long hence these cities will suffer under the judgments of God. San Francisco and Oakland are becoming as Sodom and Gomorrah, and the Lord will visit them in wrath.” LS 412.2

June 20, 1903: “The judgments of God are in our land. The Lord is soon to come. In fire and flood and earthquake, He is warning the inhabitants of this earth of His soon approach. O that the people may know the time of their visitation! We have no time to lose. We must make more determined efforts to lead the people of the world to see that the day of judgment is at hand.” LS 412.3

The Lord Has a Time Appointed—The natural heart is not to bring its own tainted, corrupting principles into the work of God. There must be no concealing of the principles of our faith. The third angel's message is to be sounded by God's people. It is to swell to the loud cry. The Lord has a time appointed when He will bind off the work; but when is that time? When the truth proclaimed for these last days shall go forth as a witness to all nations, then shall the end come. If the power of Satan can come into the very temple of God and manipulate things as he pleases, the time of preparation will be prolonged.—Letter 83, 1896. PM 389.5

Reception of Mark of the Beast Future—The change of the Sabbath is the sign or mark of the authority of the Romish church. Those who, understanding the claims of the fourth commandment, choose to observe the false sabbath in the place of the true, are thereby paying homage to that power by which alone it is commanded. The mark of the beast is the papal sabbath, which has been accepted by the world in the place of the day of God's appointment. Ev 234.1

No one has yet received the mark of the beast. The testing time has not yet come. There are true Christians in every church, not excepting the Roman Catholic communion. None are condemned until they have had the light and have seen the obligation of the fourth commandment. But when the decree shall go forth enforcing the counterfeit sabbath, and the loud cry of the third angel shall warn men against the worship of the beast and his image, the line will be clearly drawn between the false and the true. Then those who still continue in transgression will receive the mark of the beast. Ev 234.2

With rapid steps we are approaching this period. When Protestant churches shall unite with the secular power to sustain a false religion, for opposing which their ancestors endured the fiercest persecution, then will the papal sabbath be enforced by the combined authority of church and state. There will be a national apostasy, which will end only in national ruin.—Manuscript 51, 1899. Ev 235.1

The gospel is to be proclaimed in our cities. Men of learning and influence are to hear the message. Not only white men but colored men of ability are to accept the faith. These are to work for their own people, and they are to be supported in doing the work the Lord desires to have done. Ev 559.1

Much more prayer, much more Christlikeness, much more conformity to God's will, is to be brought into God's work. Outward show, an extravagant outlay of means, will not accomplish the work to be done. Many are gasping for a breath of life from heaven. They will recognize the gospel when it is brought to them in the way that God designs it to be brought. Ev 559.2

Into the busy world, filled with the din of commerce and the altercation of trade, where men were trying selfishly to get all they could for self, Christ came; and above the confusion, His voice, like the trump of God, was heard: “What shall it profit a man, if he shall gain the whole world, and lose his own soul? Or what shall a man give in exchange for his soul?” Ev 559.3