Unto thee lift I up mine eyes - We have no hope but in thee; our eyes look upward; we have expectation from thy mercy alone.
Unto thee - To God.
Lift I up mine eyes - In supplication and prayer. Nature prompts us to look up when we address God, as if he dwelt above us. It is the natural prompting of the heart that he must be the most exalted of all beings, dwelling above all. See Psalm 121:1.
O thou that dwellest in the heavens - Whose home - whose special home - is in heaven - above the sky. This is in accordance with the common feelings of people, and the common description of God in the Bible, though it is true also that God is everywhere. Compare Psalm 2:4; Psalm 11:4.