Wherefore hidest thou thy face - Why is it that I no longer enjoy thy approbation?
Holdest me for thine enemy? - Treatest me as if I were the vilest of sinners?
Wherefore hidest thou thy face - To hide the face, or to turn it away, is expressive of disapprobation. We turn away the face when we are offended with anyone. See the notes at Isaiah 1:15.
And holdest me for thine enemy - Regardest and treatest me as an enemy.