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In whose hand is the soul of every living thing - חי כל נפש nephesh col chai, "the soul of all life."

And the breath of all mankind - בשר כל ורוח veruach col besar, "and the spirit or breath of all flesh." Does not the first refer to the immortal soul, the principle of all intellectual life; and the latter to the breath, respiration, the grand means by which animal existence is continued? See Job 10:1.

In whose hand is the soul of every living thing - Margin, “Life.” The margin is the more correct rendering. The idea is, that all are under the control of God. He gives life, and health, and happiness when he pleases, and when he chooses he takes them away. His sovereignty is manifested, says Job, in the inferior creation, or among the beasts of the field, the fishes of the sea, and the fowls of heaven.

And the breath of all mankind - Margin, “Flesh of man.” The margin is in accordance with the Hebrew. The meaning is, that man is subjected to the same laws as the rest of the creation. God is a sovereign, and the same great principles of administration may be seen in all his works.

Job appeals to facts. The most audacious robbers, oppressors, and impious wretches, often prosper. Yet this is not by fortune or chance; the Lord orders these things. Worldly prosperity is of small value in his sight: he has better things for his children. Job resolves all into the absolute proprietorship which God has in all the creatures. He demands from his friends liberty to judge of what they had said; he appeals to any fair judgment.