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Whom I serve with my spirit - λατπευω Whom I worship with the profoundest religious reverence; for so the original certainly means: I not only employ all the powers of my body in this service, but all those of my soul; being thoroughly convinced of the absolute truth of the religion I preach. Probably St. Paul opposes, in this place, the spiritual worship of the Gospel to the external, or what some call the carnal, worship of the Jews. Mine is not a religion of ceremonies, but one in which the life and power of the eternal Spirit are acknowledged and experienced.

For God is my witness - The reason of this strong appeal to God is, to show to the Romans the deep interest which he felt in their welfare This interest was manifested in his prayers, and in his earnest desires to see them. A deep interest shown in this way was well suited to prepare them to receive what he had to say to them.

Whom I serve - See Romans 1:1; compare Acts 17:23. The expression denotes that he was devoted to God in this manner; that he obeyed him; and had given himself to do his will in making known his gospel.

With my spirit - Greek, ἐν enin my spirit, that is, with my “heart.” It is not an external service merely; it is internal, real, sincere. He was really and sincerely devoted to the service of God.

In the gospel of his Son - In making known the gospel, or as a minister of the gospel.

That without ceasing - ἀδιαλείπτως adialeiptōsThis word means constantly, always, without intermission. It was not only once, but repeatedly. It had been the burden of his prayers. The same thing he also mentions in regard to other churches, 1 Thessalonians 1:3; 1 Thessalonians 2:13.

I make mention - I call you to remembrance, and present your case before God. This evinced his remarkable interest in a church which he had never seen, and it shows that Paul was a man of prayer; praying not for his friends and kindred only, but for those whom he had never seen. If with the same intensity of prayer all Christians, and Christian ministers, would remember the churches, what a different aspect would the Christian church soon assume!

Always - This word should be connected with the following verse, “Always making request,” etc.

We must show love for our friends, not only by praying for them, but by praising God for them. As in our purposes, so in our desires, we must remember to say, If the Lord will, Jas 4:15. Our journeys are made prosperous or otherwise, according to the will of God. We should readily impart to others what God has trusted to us, rejoicing to make others joyful, especially taking pleasure in communing with those who believe the same things with us. If redeemed by the blood, and converted by the grace of the Lord Jesus, we are altogether his; and for his sake we are debtors to all men, to do all the good we can. Such services are our duty.